Special Journal of the Medical Academy and other Life Sciences.

Comparative analysis of international and Malaysia approaches to the treatment of patients with chronic gastritis from the point of view of evidence-based medicine.

Leah Hui Yee — 2024-10-13

Background: Chronic gastritis, often resulting from *Helicobacter pylori* infection, is a widespread gastrointestinal disorder. The condition requires evidence-based treatment approaches to ensure effective management and improved patient outcomes. This study conducts a comparative analysis of the treatment approaches for chronic gastritis in Malaysia and internationally, focusing on adherence to evidence-based medicine (EBM) practices. Understanding the similarities and differences in these approaches is critical for enhancing Malaysia's healthcare strategies.

Methods and Materials: The study employed a systematic review of relevant literature sourced from global medical databases, including PubMed, Embase, and Cochrane Library. The review focused on therapeutic options, diagnostic standards, and evidence-based protocols for managing chronic gastritis, with emphasis on both international and Malaysian healthcare systems. Studies included in the review primarily focused on adult patients diagnosed with chronic gastritis and treated using evidence-based methodologies.

Results: The analysis revealed significant parallels in the treatment protocols between Malaysia and international guidelines, particularly in the use of proton pump inhibitors (PPIs) and antibiotic regimens for *H. pylori* eradication. However, differences emerged in the implementation of advanced diagnostic tools, accessibility of healthcare services, and the influence of local antibiotic resistance patterns. While Malaysia follows global best practices, rural-urban healthcare disparities impact the consistency of treatment delivery and patient outcomes.

Conclusion: Both international and Malaysian approaches to chronic gastritis prioritize evidence-based medicine. The findings suggest that Malaysia effectively adapts international guidelines to its local healthcare context, though improvements are needed in addressing healthcare accessibility and antibiotic resistance. Enhanced implementation of EBM practices, particularly in rural areas, and personalization of treatment based on resistance patterns, could further optimize patient outcomes in Malaysia.

Healthy in ancient and modern times

Shaleni Johnson — 2024-10-13

Background: Health practices have evolved from ancient holistic approaches to modern scientifically driven methods. This comparative study aims to explore the continuity and transformation in healthcare practices from ancient times to the present, highlighting the enduring principles of wellness and the advancements in medical science.

Methods and Material: The research employs a comparative analysis of ancient health practices, such as Ayurveda and Traditional Chinese Medicine, against modern health practices influenced by scientific and technological advancements. Sources include archaeological findings, historical texts, and contemporary scientific literature.

Results: Ancient health practices emphasized a holistic approach, integrating diet, lifestyle, and spiritual practices to maintain balance and harmony. Modern health practices prioritize evidence-based treatments, technological interventions, and preventive care, leading to significant improvements in health outcomes. Both approaches highlight the importance of preventive measures, personalized care, and a comprehensive understanding of health and well-being.

Conclusion: This study reveals that despite the methodological differences, the fundamental objective of fostering health and well-being remains constant across time. Integrating ancient wisdom with modern scientific advancements offers a more holistic approach to health, addressing physical, mental, and spiritual aspects of well-being.

Comprehensive guide to tobacco control policy implementation

Govindan Chenkuttu — 2024-10-13

Background: Tobacco use remains one of the leading causes of preventable death and disease worldwide. Effective tobacco control policies are essential in mitigating these health risks. The Framework Convention on Tobacco Control (FCTC), adopted by the World Health Organization (WHO) in 2003, provides a comprehensive framework for implementing evidence-based tobacco control measures globally. This project aims to develop and implement robust tobacco control policies to reduce tobacco consumption and its associated health risks.

Methods and Materials: The project involved a comprehensive review of existing tobacco control policies, data collection on tobacco use and related health outcomes, and the development of a multi-sectoral task force. Key strategies included setting clear goals, stakeholder engagement, public awareness campaigns, and the drafting of legislative and policy documents. Implementation mechanisms such as enforcement and evaluation systems were also established to ensure compliance and measure the policy's impact.

Results: The implementation of the tobacco control policies resulted in a significant reduction in smoking prevalence and exposure to secondhand smoke. Public awareness of the health risks associated with tobacco use increased, and there was enhanced support for smoking cessation services. The project also identified best practices and strategies that can be adopted by other regions to achieve similar outcomes.

Conclusion: This project highlights the importance of comprehensive research, effective coordination, and well-planned implementation in developing and executing tobacco control policies. The findings and recommendations presented serve as a valuable resource for policymakers and public health professionals aiming to reduce smoking rates and protect public health. Continued collaboration and adaptation of these strategies are essential for sustaining the progress made in tobacco control.

Amnesia and homework

Irina Vasilieva — 2024-10-13

Introduction: In humans, the phenomenon of temporally graded retrograde amnesia has been described in the clinic and the laboratory for more than 100 years. The memory f\deficit can occur against a background of intact intellectual and perceptual functions.

Material and methods: There were analyzed articles from the PubMed database from the last 5 years 2019-2024, mentioning such words as “amnesia”, “homework”.

Results: Amnestic syndrome is narrower than once believed in the sense that a number of learning and memory abilities are preserved. The brain system damage in amnesia has only a temporary role in memory. In the 1950 edition of the Encyclopedia of Educational Research H.J. Otto wrote “compulsory homework does not result in sufficiently improved academic accomplishments to justify retention” [1]. Eighteen years later P.R Wildman went a step further, starting that “whenever homework crowds out social experience, outdoor recreation, and creative activities and whenever it usurps time devoted to sleep, it is not meeting the basic needs of children and adolescents” [2].

Conclusion: Thus, as Otto’s remark exemplifies, homework fell out of favor. Homework, it was believed could accelerate knowledge acquisition. Wildman expressed the concern of the time that too much emphasis on school would lead to the neglect of other areas of personal fulfillment. Not all amnesias, results from brain damage. Amnesia may be produced by severe emotional trauma or naturally occurring changes in state or arousal [3-5]. Improves creative activity total quality management as a predictor of artificial intelligence provides competitive marketing, proven and by the role of social networks in reducing stress [6,7], confirming that amnesia has only a temporary role in memory.

Role of glucose in regulating menstrual cycle

Irina Vasilieva — 2024-10-14

Goal of the study: To find correlation between estrogen hormone and glucose intake.

Introduction: The main estrogens: estradiol, estrone and their acyl-esters have been studied essentially related to their classical estrogenic functions. However their main effect in the body is probably the sustained control of core energy metabolism. With regard to energy, the estrogen molecular species act through control of glucose availability.

Material and methods: There were analyzed articles from the PubMed database, from the last 5 years 2019-2024, mentioning such words as “estrogen”, “glucose”, “ menstrual cycle” [1].

Results: Estrogens play a paramount and continued regulatory role, to maintain energy (lipid / glucose) homeostasis. Estrogens have extensive and powerful control of energy homeostasis. Premenopausal women exhibit enhanced insulin sensitivity and reduced incidence of type 2 diabetes, compared with age matched men, but this advantage disappears after menopause with disrupted glucose homeostasis, in part owing to a reduction in circulating 17 β –estradiol (E2). Moreover a study shows the efficacy of a glucagon like peptide-1 and estrogen dual agonist (GLP1-E2) in pancreatic islet protection. The enzymes that are involved in the menstrual cycle are β-glucoronidase, thought to be involved in the final stages of mucopolysaccharide breakdown.

Conclusion: So far there is limited information on the major role played by different forms of physiological estrogens in the control of energy metabolism at the whole body level. E2 protects the functionality of the pancreatic β cells, preventing apoptosis, adapting their function to insulin resistance and maintaining their insulin content. The lack of E2 availability also increases hepatic insulin clearance. Estrogen receptor α plays a crucial role in regulating glucose.

However, the underlying mechanisms remain incompletely understood and therefore studies on the maintenance of (lipid / glucose) homeostasis are ongoing [2-10] in various neuro-endocrine and visceral multisystem biomedical areas, where the diagnostic role of markers is essential [11,12].