Obesity and prostate cancer: the influence of metabolic syndromes


  • Dr.Ghassan Salibi Charisma University




Obesity, prostate cancer


Obesity is a significant issue for public health that is linked to a variety of chronic ailments, including cancer. Prostate cancer is the most frequent disease in men, and there is growing evidence that obesity might impact prostate cancer risk and prognosis. This article reviews the present body of scientific knowledge on the link between obesity and prostate cancer, emphasizing the involvement of metabolic syndromes. It examines the evidence indicating a direct relationship between obesity and prostate cancer risk and the likely processes behind this link, such as alterations in hormonal, immune-modulatory, and metabolic pathways. Furthermore, it investigates the influence of metabolic disorders, including insulin resistance and metabolic syndrome.


Bandini, M., Gandaglia, G., & Briganti, A. J. C. O. i. U. (2017). Obesity and prostate cancer. 27(5), 415-421.

Baron, J. J. T. (1996). Cancer epidemiology and prevention. 269-289.

Beebe‐Dimmer, J. L., Dunn, R. L., Sarma, A. V., Montie, J. E., & Cooney, K. A. J. C. I. I. J. o. t. A. C. S. (2007). Features of the metabolic syndrome and prostate cancer in African‐American men. 109(5), 875-881.

Ferlay, J., Ervik, M., Lam, F., Colombet, M., Mery, L., Piñeros, M., . . . Bray, F. J. L., France: international agency for research on cancer. (2018). Global cancer observatory: cancer today. 3(20), 2019.

Gapstur, S., Kopp, P., Gann, P., Chiu, B. C., Colangelo, L., & Liu, K. J. I. j. o. o. (2007). Changes in BMI modulate age-associated changes in sex hormone binding globulin and total testosterone, but not bioavailable testosterone in young adult men: the CARDIA Male Hormone Study. 31(4), 685-691.

Hayes, R. B., Ziegler, R. G., Gridley, G., Swanson, C., Greenberg, R. S., Swanson, G. M., . . . Prevention. (1999). Dietary factors and risks for prostate cancer among blacks and whites in the United States. 8(1), 25-34.

Hsing, A. W., & Devesa, S. S. J. E. r. (2001). Trends and patterns of prostate cancer: what do they suggest? , 23(1), 3-13.

Hsing, A. W., Reichardt, J. K., & Stanczyk, F. Z. J. T. P. (2002). Hormones and prostate cancer: current perspectives and future directions. 52(3), 213-235.

Hsing, A. W., Sakoda, L. C., & Chua Jr, S. C. J. T. A. j. o. c. n. (2007). Obesity, metabolic syndrome, and prostate cancer. 86(3), 843S-857S.

Hsing, A. W., Sakoda, L. C., & Chua, S. C., Jr. (2007). Obesity, metabolic syndrome, and prostate cancer. The American Journal of Clinical Nutrition, 86(3), 843S-857S. doi:10.1093/ajcn/86.3.843S %J The American Journal of Clinical Nutrition

Kaaks, R., Lukanova, A., Sommersberg, B. J. P. c., & diseases, p. (2000). Plasma androgens, IGF-1, body size, and prostate cancer risk: a synthetic review. 3(3), 157-172.

Khanna, D., Khanna, S., Khanna, P., Kahar, P., & Patel, B. M. J. C. (2022). Obesity: A chronic low-grade inflammation and its markers. 14(2).

Laaksonen, D. E., Lakka, H.-M., Niskanen, L. K., Kaplan, G. A., Salonen, J. T., & Lakka, T. A. J. A. j. o. e. (2002). Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. 156(11), 1070-1077.

Laukkanen, J. A., Laaksonen, D. E., Niskanen, L., Pukkala, E., Hakkarainen, A., & Salonen, J. T. (2004). Metabolic Syndrome and the Risk of Prostate Cancer in Finnish Men: A Population-Based Study. Cancer Epidemiology, Biomarkers & Prevention, 13(10), 1646-1650. doi:10.1158/1055-9965.1646.13.10 %J Cancer Epidemiology, Biomarkers & Prevention

Lund Håheim, L., Wisløff, T., Holme, I., & Nafstad, P. J. A. j. o. e. (2006). Metabolic syndrome predicts prostate cancer in a cohort of middle-aged Norwegian men followed for 27 years. 164(8), 769-774.

Martin, R. M., Vatten, L., Gunnell, D., Romundstad, P., Nilsen, T. I. J. C. C., & Control. (2009). Components of the metabolic syndrome and risk of prostate cancer: the HUNT 2 cohort, Norway. 20, 1181-1192.

McGrowder, D. A., Jackson, L. A., & Crawford, T. V. J. A. P. J. o. C. P. (2012). Prostate cancer and metabolic syndrome: is there a link? , 13(1), 1-13.

Nelson, W. G., De Marzo, A. M., DeWEESE, T. L., & Isaacs, W. B. J. T. J. o. u. (2004). The role of inflammation in the pathogenesis of prostate cancer. 172(5), S6-S12.

Parikesit, D., Mochtar, C. A., Umbas, R., & Hamid, A. R. A. H. (2016). The impact of obesity towards prostate diseases. Prostate International, 4(1), 1-6. doi:https://doi.org/10.1016/j.prnil.2015.08.001

Platz, E. A., Leitzmann, M. F., Rifai, N., Kantoff, P. W., Chen, Y.-C., Stampfer, M. J., . . . Prevention. (2005). Sex steroid hormones and the androgen receptor gene CAG repeat and subsequent risk of prostate cancer in the prostate-specific antigen era. 14(5), 1262-1269.

Ranasinghe, P., Mathangasinghe, Y., Jayawardena, R., Hills, A., & Misra, A. J. B. p. h. (2017). Prevalence and trends of metabolic syndrome among adults in the asia-pacific region: a systematic review. 17(1), 1-9.

Sfanos, K. S., & De Marzo, A. M. J. H. (2012). Prostate cancer and inflammation: the evidence. 60(1), 199-215.

Sigit, F. S., Tahapary, D. L., Trompet, S., Sartono, E., Willems van Dijk, K., Rosendaal, F. R., & de Mutsert, R. (2020). The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies. Diabetology & Metabolic Syndrome, 12(1), 2. doi:10.1186/s13098-019-0503-1

Sun, J., Hsu, F. C., Turner, A. R., Zheng, S. L., Chang, B. L., Liu, W., . . . Xu, J. J. T. P. (2006). Meta‐analysis of association of rare mutations and common sequence variants in the MSR1 gene and prostate cancer risk. 66(7), 728-737.

Tande, A. J., Platz, E. A., & Folsom, A. R. J. A. j. o. e. (2006). The metabolic syndrome is associated with reduced risk of prostate cancer. 164(11), 1094-1102.

Tzenios, N., Tazanios, M., & Chahine, M. (2022). In the United States, Obesity Is So Prevalent Could It Be Described as a Pandemic?

Tzenios, N., Tazanios, M. E., & Chahine, M. (2022). The impact of body mass index on prostate cancer: An updated systematic review and meta-analysis. 101(45), e30191. doi:10.1097/md.0000000000030191.

Tzenios, N. . (2019). The Impact of Health Literacy on Employee Productivity: An Empirical Investigation . Empirical Quests for Management Essences, 3(1), 21–33. Retrieved from https://researchberg.com/index.php/eqme/article/view/83.

Tzenios, N. (2019). The Determinants of Access to Healthcare: A Review of Individual, Structural, and Systemic Factors. Journal of Humanities and Applied Science Research, 2(1), 1–14. https://journals.sagescience.org/index.php/JHASR/article/view/23.

Tzenios, N. . (2020). Examining the Impact of EdTech Integration on Academic Performance Using Random Forest Regression. ResearchBerg Review of Science and Technology, 3(1), 94–106.https://researchberg.com/index.php/rrst/article/view/84.

Tzenios, N. (2023). A New Hallmark of Cancer: Stemness. Special Journal of the Medical Academy and Other Life Sciences., 1(1). https://doi.org/10.58676/sjmas.v1i1.3.

Sharma, P. R., & Tzenios, N. (2023). Impact of Cirrhosis and Alcohol on Mortality Rates and Mitigation Efforts. Special Journal of the Medical Academy and Other Life Sciences., 1(1). https://doi.org/10.58676/sjmas.v1i1.10.

Professor Nikolaos Tzenios Ph.D., FRSPH, FRSM, FAAMFM, FWAMS, FMRS, AcIASS, mRSB, DABAAHP. (2022). CONTRIBUTE TO RAISING AWARENESS IN A COMMUNITY. EPRA International Journal of Multidisciplinary Research (IJMR), 8(12), 122–124. http://eprajournals.net/index.php/IJMR/article/view/1252.(https://doi.org/10.36713/epra12021).

Tzenios, N. (2020). Clustering Students for Personalized Health Education Based on Learning Styles. Sage Science Review of Educational Technology, 3(1), 22–36. https://journals.sagescience.org/index.php/ssret/article/view/22.

Tzenios, N. (2022). Student-led Learning Theory. Cambridge Open Engage. https://doi.org/10.33774/coe-2022-0x2bx.

Tzenios, N. (2022). Academic Doctoral Learning Plan. Cambridge Open Engage. https://doi.org/10.33774/coe-2022-7twh9.

Tzenios N, Tazanios M, Chahine M. The Relationship between Association between Blood Pressure and Risk of Cancer Development. Preprints.org; 2022. https://doi.org/10.20944/preprints202211.0353.v1.

Tzenios, N., Tazanios, M. E., & Chahine, M. (2022). Combining Influenza and COVID-19 Booster Vaccination Strategy to Improve Vaccination Uptake Necessary for Managing the Health Pandemic: A Systematic Review and Meta-Analysis. Vaccines, 11(1), 16. https://doi.org/10.3390/vaccines11010016.

Tzenios, N. (2022). Interprofessional Program Design Project to improve Nursing students’ attitudes toward collaborative practice. Cambridge Open Engage. https://doi.org/10.33774/coe-2022-hsxz7.

Tzenios, N.; Tazanios, M.; Chahine, M. The impact of BMI on Ovarian Cancer- An Updated Systematic Review and Metanalysis. Preprints 2022, 2022110251 (https://doi.org/10.20944/preprints202211.0251.v1).




How to Cite

Salibi, G. (2023). Obesity and prostate cancer: the influence of metabolic syndromes . Special Journal of the Medical Academy and Other Life Sciences., 1(2). https://doi.org/10.58676/sjmas.v1i2.13

Most read articles by the same author(s)