Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review.

Abstract

According to the World Health Organization (WHO), coronavirus infection (COVID-19, (COronaVIrus Disease 2019) is an infectious disease caused by the SARS-CoV-2 virus [1]. SARS-CoV-2 virus, Severe Acute Respiratory Syndrome-related coronavirus 2. Initially considered pulmonary - respiratory pathology, then it turned out to be poly-systemic, with multi-inflammation of many other organs, and central nervous system. Multisystem inflammatory syndrome in adults (MIS-A) [2], SARS-CoV-2 liver infection [3]. In pediatrics Multisystem inflammatory syndrome in children (MIS-C) or PMIS-TS (Pediatric MIS temporarily associated with SARS-CoV-2 infection) [4,5], SARS-COV-2/ COVID-19 in children induce Kawasaki-Like Disease [6]. Neurological manifestations [7], recurrence of COVID-19 infection with meningitis without pulmonary involvement [8]. Brain damage in COVID is primarily neurological, as a material signaling pathway of inflammatory COVID-infection of cerebral vessels. This is important, from the release of these patients, from additional stress, suffering, stigmatization in society, their isolation, intimidation, coercion (bullying) with violation and restriction of their rights. Since, concomitantly with inflammatory lesions of many organs, cognitive deficits are a component of the post-acute consequences of COVID-19 (PASC), where the role of the kynurenine pathway is significant with temporary cognitive impairment [9]. The main pathway for the breakdown of tryptophan is an amino acid, without which the synthesis of serotonin is impossible, which controls the cycles of sleep and wakefulness, which is the precursor of the sleep hormone melatonin

 In patients with COVID-19, an imbalance of T-helpers 1 and 2 leads to a cytokine storm that can contribute to myocardial damage [10]. MIS is conditioned caused by immunocompromising (IC) CHAOS - [C]ardiovascular Compromise: shock; [H]omeostasis; [A]poptosis; [O]rgan Dysfunction; [S]uppression of the Immune System with the development of Systemic inflammatory response syndrome (SIRS) and Multiple Organ Dysfunction Syndrome (MODS) [11,12]. With pronounced multiple and other symptoms: Electro - Ion Membrane Distress Syndrome (Syndrome Maria & Irina Vasilieva) [13,14] with membrane manifestations of electrical storm or electromembrane paralysis; Capillary Leak Syndrome; Microcirculatory-Mitochondrial Distress Syndrom [15,16]. Also described: Overlap mechanisms of transient global amnesia and COVID-19 infection [17]; Hypokalemia-stroke mimic [18]; Differential diagnosis of cacosmia and dysgeusia in COVID-19 pandemic [19].