Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus
DOI:
https://doi.org/10.58676/sjmas.v2i4.70Abstract
Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of the virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores the role of Acute Vascular Distress Syndrome (AVDS) in the development of MIS in both adults (MIS-A) and children (MIS-C), providing a comprehensive overview of modern research and treatment approaches for severe coronavirus infections.
Methods and Materials: This review synthesizes findings from multiple studies and clinical reports to analyze the mechanisms by which SARS-CoV-2 induces AVDS and subsequently MIS. Key materials include molecular and cellular research data, clinical case studies, and treatment protocols. Diagnostic tools such as PCR and serological testing, as well as various biomarkers like neurofilament light chain and galectin-3, are discussed to elucidate their roles in identifying and managing severe COVID-19 cases.
Results: The interaction between SARS-CoV-2 and host endothelial cells, mediated by ACE2 receptors, triggers a cascade of inflammatory responses leading to AVDS. This syndrome is characterized by severe endothelial dysfunction, cytokine storms, and mitochondrial distress, which collectively contribute to the pathogenesis of MIS. Clinical evidence indicates that AVDS is a critical factor in the severity of COVID-19, with widespread implications for multiple organ systems, including the central and peripheral nervous systems.
Conclusion: Understanding the role of AVDS in MIS development offers valuable insights into the pathophysiology of severe COVID-19. Effective management requires a multifaceted approach, combining antiviral therapies, immunomodulators, and supportive treatments like extracorporeal membrane oxygenation (ECMO). Future research should focus on targeted therapies to mitigate endothelial damage and improve patient outcomes in critical COVID-19 cases.
References
Vasiliev I., Vasilieva Maria, Vasilieva Irina. (2023). Molecular pathological biology of Coronavirus infection SARS-CoV-2. Lambert Academic Publishing. UK. https://www.researchgate.net/publication/376886306_Ilie_Vasiliev_Maria_Vasilieva_Irina_Vasilieva_Molecular_pathological_biology_of_Coronavirus_infection_SARS-CoV-2].
Constantin T., Pék T., Horváth Z. et al. (2023). Multisystem inflammatory syndrome in children (MIS-C): Implications for long COVID. Inflammopharmacol., https://doi.org/10.1007/s10787-023-01272-3 https://link.springer.com/article/10.1007/s10787-023-01272-3
Revenco Ninel, Foca S., Jivalcovschi A., Ziaev L., Vasilieva Irina, Vasilieva Maria, Vasiliev Ilie, et al. (2020). Challenges of Pediatric Multisystem Inflammatory Syndrome Associated with Covid-19 - A Series of Clinical Cases. Biomedical Research and Clinical Reviews. 1(4); DOI: 10.31579/2692-9406/027
Zahornacky O., Porubčin Š., Rovnakova A., Jarcuska P. (2023) Multisystem Inflammatory Syndrome in Adults Associated with Recent Infection with COVID-19. Diagnostics (Basel). , 4;13(5):983. doi: 10.3390/diagnostics13050983. PMID: 36900127; PMCID: PMC10000501
Duloquin G., Pommier T., Georges M., Giroud M., et al. (2024). Is COVID-19 Infection a Multiorganic Disease? Focus on Extrapulmonary Involvement of SARS-CoV-2. Journal of Clinical Medicine. 13(5):1397. https://doi.org/10.3390/jcm13051397
Vasilieva Maria,⁎ Vasiliev Ilie, Vasilieva Irina, and Groppa Stanislav. TU-237. (2022). Recurrence of COVID-19 infection with meningitis without pulmonary involvement. Clin Neurophysiol. 141: S53. doi: 10.1016/j.clinph.2022.07.141.
Epub 2022 Sep 1. PMCID: PMC9436445.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436445/ PubMed Central. USA
https://europepmc.org/article/pmc/pmc9436445 Europe PMC
https://hollis.harvard.edu/permalink/f/1mdq5o5/TN_cdi_unpaywall_primary_10_1016_j_clinph_2022_07_141 Harvard Library. USA
https://trails-um.primo.exlibrisgroup.com/discovery/search?query=any,contains,1388-2457%20Maria%20Vasilieva%20Ilie%20Vasiliev%20Irina%20Vasilieva%20Stanislav%20Groppa&tab=ML_Payne_Everything&search_scope=OneSearch_Everything&vid=01TRAILS_UM:01TRAILS_UM&offset=0 USA The University of Montana
https://www.sciencedirect.com/science/article/pii/S1388245722004679?via%3Dihub Abstracts of the 32nd International Congress of Clinical Neurophysiology (ICCN) of the IFCN, September 4-8, 2022, Geneva, Switzerland
https://gimikatalogus.elte.hu/EITRecord/158781169 Hungary. Eötvös Loránd University (ELTE)
https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/es/covidwho-2177651 World Health Organization WHO
Jean-Laurent Casanova et al. (2024). Interferon-γ and infectious diseases: Lessons and prospects. Science384, eadl2016., DOI:10.1126/science.adl2016
Coronavirus disease (COVID-19). (2023). World Health Organization (WHO).
https://www.who.int/health-topics/coronavirus/coronavirus#tab=tab_1
Shchelkanov M. Yu., Popova A. Yu., Dedkov V. G., Akimkin V. G., et al. (2020). History of the study and modern classification of coronaviruses (Nidovirales: Coronaviridae) //Infection and Immunity; 10; 2; 221—246. doi:10.15789/2220-7619-H0I-1412 Archived from the original on June 25, 2020. https://iimmun.ru/iimm/article/view/1412
A Chronicle on the SARS Epidemic. (2003). Chinese Law & Government. 36 (4): 12–15. https://doi.org/10.2753/CLG0009-4609360412. ISSN 0009-4609. S2CID 219305114. Archived from the original on 2 October 2020. Retrieved 12 June 2020.
Taxonomy of viruses (English) on the website of the International Committee on Taxonomy of Viruses (ICTV). (Date accessed: July 19, 2019). https://ictv.global/taxonomy
Wang, Y., Tsai, CH., Wang, YC. et al. SARS-CoV-2 nucleocapsid protein, rather than spike protein, triggers a cytokine storm originating from lung epithelial cells in patients with COVID-19. Infection (2023). https://doi.org/10.1007/s15010-023-02142-4
Jounieaux, V., Basille, D., Abou-Arab, O. et al. Pure SARS-CoV-2 related AVDS (Acute Vascular Distress Syndrome). BMC Infect Dis 21, 122 (2021). https://doi.org/10.1186/s12879-021-05805-5
Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, et al. (2023). Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts. Sci Transl Med., 9;15(708):eabq1533. doi: 10.1126/scitranslmed.abq1533. Epub 2023 Aug 9. PMID: 37556555
McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, et al. (2021). Role of miR-2392 in driving SARS-CoV-2 infection. Cell Rep. 37(3):109839. doi: 10.1016/j.celrep.2021.109839. Epub 2021 Sep 30. PMID: 34624208; PMCID: PMC8481092
Vasiliev I. (2020). Mitochondrial of critical obstetric situations in the complex multi-organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute multi-organ dysfunction. Journal of Computational Methods in Molecular Design., 10:2.
Vasiliev I., Vasilieva Maria, Vasilieva Irina et al. (2018). Suspendarea sindromului detresei microcirculator–mitocondriale prin recrutarea microcirculator–mitocondrială a situațiilor critice obstetricale. Suspension of microcirculatory–mitochondrial distress syndrome by microcirculatory–mitochondrial recruitment of critical obstetric situations. Congres Național al Societății de Obstetrică și Ginecologie din România. National Congress of the Society of Obstetrics and Gynecology from Romania, 167-168. https://ibn.idsi.md/vizualizare_articol/152565
Vasiliev I., Vasilieva Irina, Vasilieva Maria. (2019). Prevention of the development of multi organ dysfunction syndrome: is achieved by complex methods of recruiting microcirculatory-mitochondrial distress syndrome, in which the pCO2> (AV gap) increases.
Sheridan, Cormac. Coronavirus and the race to distribute reliable diagnostics (English) // Nature Biotechnology : journal. — Nature Publishing Group, 2020. — 19 February. — doi:10.1038/d41587-020-00002-2
Vasilieva Irina. (2024). Role of Neurofilament light chain in neurological disease. Scientific advisor: Visnevschi Anatolie, MD, PhD, Professor, Department of Laboratory Medicine, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova. The 10th International Medical Congress For Students And Young Doctors. Abstract Book. Chișinău. Republic of Moldova.,198. https://medespera.md/en/books?page=10
Loeffler T, Schilcher I, Flunkert S, Hutter-Paier B Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value. Front Neurosci. 2020 Jun 11;14:579. doi: 10.3389/fnins.2020.00579. PMID: 32595447; PMCID: PMC7300175
Vasilieva Irina, Vasiliev I. (2023). Rolul diagnostic al galectin-3 în afecțiuni cardiace. Diagnostical role of galectin-3 in heart disease. Conference "Research in biomedicine and health: quality, excellence and performance. Chişinău, Moldova, October 18-20., 90-90. Moldovan Journal of Health Sciences., 3:10: Annex 1
https://ibn.idsi.md/vizualizare_articol/193369
https://repository.usmf.md/handle/20.500.12710/25508
Schroeder JT, Bieneman AP. The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3. Front Immunol. 2022 Mar 22;13:831763. doi: 10.3389/fimmu.2022.831763 . PMID: 35392091; PMCID: PMC8982143
Schaller J, Gerber SS. The plasmin-antiplasmin system: structural and functional aspects. Cell Mol Life Sci. 2011 Mar;68(5):785-801. doi:10.1007/s00018-010-0566-5. Epub 2010 Dec 7. PMID: 21136135
Li Y, Cui X, Zhu N, Lin Y and Li X (2024) Elevated hyaluronic acid levels in severe SARS-CoV-2 infection in the post-COVID-19 era. Front. Cell. Infect. Microbiol. 14:1338508. doi: 10.3389/fcimb.2024.1338508
Vasilieva Maria, Vasilieva Irina, Vasiliev I., Groppa, S., Ghidirim, G. et al. (2020). Intralipid in the Target Treatment of Lipid Peroxidation Disorder Caused by Oxidative and Nitro-Galogenic Stress in Patients with SARS-Cov2 / COVID / 19. Journal of Advances in Medical and Pharmaceutical Sciences, 22(11), 20–30. https://doi.org/10.9734/jamps/2020/v22i1130202
https://journaljamps.com/index.php/JAMPS/article/view/470
http://dspace.onua.edu.ua/handle/11300/24496?locale-attribute=en
Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):168-75. doi: 10.1161/01.atv.0000051384.43104.fc PMID: 12588755
Lambert DW, Yarski M, Warner FJ, et al. (2005). Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem. ;280(34):30113-9. doi: 10.1074/jbc.M505111200. Epub 2005 Jun 27. PMID: 15983030; PMCID: PMC8062222 https://pubmed.ncbi.nlm.nih.gov/15983030/
Kabbani Nadine, Olds James L. (2020). Does COVID-19 infect the brain? If so, smokers might be at a higher risk (англ.) // Molecular Pharmacology Journal., 97:5:351—353. doi:10.1124/molpharm.120.000014. PMID 32238438 Baig A. M. (2020).
Neurological manifestations in COVID-19 caused by SARS-CoV-2. CNS Neuroscience & Therapeutics., 26:5:499—501. doi:10.1111/cns.13372. PMID 32266761
Solis AG., Bielecki P., Steach HR., Sharma L., et al. (2019). Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature., 573:69–74. doi: 10.1038/s41586-019-1485-8
Zhu W., Guo S., Homilius M., Nsubuga C., Wright SH., Quan D., et al. (2022) PIEZO1 mediates a mechanothrombotic pathway in diabetes. Sci Transl Med. 14:k1707. doi: 10.1126/scitranslmed.abk1707
Vasiliev I., Vasilieva M., Vasilieva I., Catereniuc I. et al. (2015) The Extracorporeal Bio-Xeno Perfusion (myelo-timo-spleen) in Multi-organ Supportive Therapy (MOST) as a Modulator of Energy, for Immuno Correction Compensatory Anti-Inflammatory Response Syndromes, and Persistent Inflammation, Immunosuppression, Catabolism, and Multi-organ Dysfunction. J Anesth Pati Care 1(1): 104. doi:10.15744/2456-5490.1.104 https://www.annexpublishers.com/articles/JAPC/1104-The-Extracorporeal-Bio-Xeno-Perfusion-myelo-timo-spleen-in-Multi-organ-Supportive-Therapy.pdf
Vasiliev I., Vasilieva M., Vasilieva I., Catereniuc I. et al. (2016). Aggressiveness Syndrome Hyperantiinflamatory Immune CHAOS DIissonance and Extracorporeal Myelotimosoleen Perfusia. Tolyatti Medical Council; 3-4: 64-67. eLIBRARY ID: 27208738 EDN: WXKQDF https://elibrary.ru/wxkqdf https://elibrary.ru/item.asp?id=27208738
Vasiliev I. Respiratory support with alveolar recruitment for complex treatment of acute lung injury and acute respiratory distress syndrome. (2009). Krasnoyarsk: International Congress for Respiratory Support. Book of Abstracts III International Congress for Respiratory Support Krasnoyarsk.,2-7.
Vasiliev I., Bogdan V., Nistor V., Solodchin S. (1993). The extracorporeal bio-xeno perfusion as a complex therapeutic component of the treatment of septicemia on the background of associated injury. Courr Med., 2:56-59.
Vasiliev I., Malachi M., Niculita I. (1996). The extracorporeal bio-xeno perfusion (timo-spleen) for the complex treatment of systemic lupus erythematosus. Courr Med., 2:41-43.
Vasilieva Maria. Vasiliev I. Vasilieva Irina. (2014). Bioperfusion in multiple organ support therapy (MOST) for Acute Lung Injury syndrome and Acute Respiratory Distress syndrome. International Congress on Hemostasiology, Anesthesiology and Intensive Care “Black Sea Pearl”. Odessa. Ukraine.
Vasilieva Maria. Vasilieva Irina. Vasiliev I., Litarczek G., D’Ambra M. Friptu V., Gladun S., Duug V., Vartanov V., Stavrou I., Tarabrin O. (2018).Vasiliev I., Vasilieva Maria, Vasilieva Irina, et al. (2018). De-Instalation of the Multi - Organic Dysfunction syndrome by associating the Mitochondrial Microcirculatory recruitment with Multiple Organ Support Therapy in Extracorporeal Life Support Organization. Perinatology Bulletin Journal of Research and Practice. Supplement., 3:6.
https://www.mama-copilul.md/images/buletin-perinatologic/BP_2018/3_2018_supliment.pdf
Lüscher TF, Barton M. (1997) Biology of the endothelium. Clin Cardiol., 20(11 Suppl 2): II-3-10. PMID: 9422846. https://pubmed.ncbi.nlm.nih.gov/9422846/
Vasilieva I., Vasilieva M., & Vasiliev I. (2023). Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review. Special Journal of the Medical Academy and Other Life Sciences., 1(7). https://doi.org/10.58676/sjmas.v1i7.41
Bolevich S.S., Bolevich S. S. (2020). Complex mechanism of COVID-19 development. The Sechenov Medical Journal.,11:2. https://doi.org/10.47093/2218-7332.2020.11.2.50-61
Azoitei, N., Heller, S. & Kleger, A. Pandemic punch: SARS-CoV-2 hits pancreas. Sig Transduct Target Ther 9, 100 (2024). https://doi.org/10.1038/s41392-024-01807-2
Revenco N., Rodica E., Silvia F., Balanuta A Mihaela, Vasilieva Irina, Vasilieva Maria, Vasiliev I. et al. (2021) SARS-COV-2/COVID19 Induce Kawasaki-Like Disease in Children Experience of Republic of Moldova: A Report of Five Cases. Biomedical Research and Clinical Reviews. 3(3):1-6. doi: 10.31579/2692-9406/055
https://www.auctoresonline.org/uploads/articles/1625205684Galley_Proof-SARS.pdf
Navarrete ML, Cerdeño MC, Serra MC, Conejero R. (2013). Síndrome de distrés mitocondrial y de la microcirculación en el paciente crítico. Implicaciones terapéuticas [Mitochondrial and microcirculatory distress syndrome in the critical patient. Therapeutic implications]. Med Intensiva.;37(7):476-84. Spanish. doi: 10.1016/j.medin.2013.03.001. Epub 2013 Sep 7. Erratum in: Med Intensiva. 2014 Jan-Feb;38(1):63. PMID: 24018281
Vasiliev I., Vasilieva Maria, Vasilieva Irina. (2021) E-Book. Forty Years Success of No Maternal Mortality in Critical Obstetrics on the Operating Table. A decrease in the increased marker of tissue hypoxia pCO2> (AV-gap) in microcirculatory-mitochondrial distress syndrome in critical obstetrics is achieved by complex methods of recruiting microcirculatory-mitochondrial distress syndrome. Biomedical Research and Clinical Reviews. 4(1); DOI: 10.31579/2692-9406/067
D’Ambra M. Immunotherapy in Some Types of Tumors. Paris. France: World Congress on Immuno Oncology and Clinical Pharmacy; 2019. https://www.itmedicalteam.pl/conference-abstracts-files/2254-6081-C2-023-008.pdf
Vasilieva Irina, Vasilieva Maria, Vasiliev I., Groppa S. et al. (2019). Role of pCO2 (AV gap) of Multi Organ Dysfunction Syndrome. Journal of Biomedical and Pharmaceutical Sciences., 2:2:2-5.
https://repo.odmu.edu.ua/xmlui/handle/123456789/7338
https://repo.odmu.edu.ua/xmlui/bitstream/handle/123456789/7338/Tarabrin.pdf?sequence=1&isAllowed=y
Wang, P., Silke, J. (2024). RIPK1 and necroptosis role in premature aging. Nat Cell Biol 26, 508–509. https://doi.org/10.1038/s41556-024-01390-2
Yang, Y., Zhang, J., lv, M. et al. (2024). Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1. Nat Cell Biol 26, 567–580 . https://doi.org/10.1038/s41556-024-01374-2
Irina Vasilieva, Maria Vasilieva, Vasiliev I., Malakhova M., Groppa S., Ghidirim Gh., Tofan-Scutaru L., Valentina Diug, et al. (2020).The manifestation of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) Maria & Irina Vasilieva syndrome. Summaries of the ”Vasile Dobrovici” Conference and the National Congress of UroGynecology. 26-28 November 2020. Ginecologia., 30 (4):28, S2
https://revistaginecologia.ro/system/revista/53/1-42.pdf
Vasiliev I., Vasilieva Maria, Vasilieva Irina, Ghicavîi V. et al. (2019). The recruitment of microcirculatory-mitochondrial of critical obstetric situations in the complex multi-organ support therapy reduces pCO2 (AV gap) and the development of the syndrome of acute multi-organ dysfunction. Biochemistry & Molecular Biology Journal., 5:22.
Jiaming Su, Si Shen, Ying Hu, Shiqi Chen, Leyi Cheng, et al. (2022). SARS-CoV-2 ORF3a inhibits cGAS-STING-mediated autophagy flux and antiviral function. J of Medical Virusology. https://doi.org/10.1002/jmv.28175]
Riaz M., Sultana R., Ahmad J., Mehmood A., et al. (2024). Autophagy-related genes mediated mitophagy in yeast, mammals, and higher plants. Cell Mol Biol (Noisy-le-grand)., 70(1):1-11. doi: 10.14715/cmb/2024.70.1.1. PMID: 38372120
Agnese De Mario, Donato D'Angelo, Giuseppe Zanotti, Anna Raffaello et al. (2023). The mitochondrial calcium uniporter complex–A play in five acts. Cell Calcium., 112 https://doi.org/10.1016/j.ceca.2023.102720
Watanabe A, Maeda K, Nara A, Hashida M, Ozono M, Nakao A, Yamada A, Shinohara Y, Yamamoto T. Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells. FEBS Open Bio. 2022 Apr;12(4):811-826. doi: 10.1002/2211-5463.13371 . Epub 2022 Feb 23. PMID: 35060355; PMCID: PMC8972046.
Yasemin Sancak et al., EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex.Science342,1379-1382(2013).
doi:10.1126/science.1242993
Vasilieva Maria, Vasilieva Irina, Vasiliev I., Malakhova M., et al. (2019). Electro-Ion membrane distress syndrome induces chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Journal of Clinical Research in Anesthesiology., 2:2:1-6. https://asclepiusopen.com/journal-of-clinical-research-in-anesthesiology/volume-2-issue-2/3.pdf
Vasilieva Irina, Vasilieva Maria, Vasiliev I. et al. (2018). Triphosphoric acid, donated, restores heart rhythm disturbances caused by energetically deficient, mitochondrial hypercalcaemia to Ca++ mpt pore lesion. Journal of Clinical Research in Anesthesiology., 1:1-3.
https://asclepiusopen.com/journal-of-clinical-research-in-anesthesiology/volume-1-issue-2/6.pdf
Vasilieva Irina, Vasilieva Maria, Vasiliev I., Malakhova M., Groppa S., Ghidirim Gh., Tofan-Scutaru L., Valentina Diug, et al. (2020). În Manifestarea SindromuluiI de Oboseală Cronică / Encefalomielită Mialgică (CFS / ME) contribue Sindromul MARIA&IRINA VASILIEVA. Zilele Medicale Vasile Dobrovici. Congresul Național de Uroginecologie. 26-28 noiembrie 2020. https://www.researchgate.net/publication/348065714_E-Poster_Sindrom_MariaIrina_Vasilieva
Yang, K., Liu, S., Yan, H. et al. (2023). SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells. Sig Transduct Target Ther 8, 276. https://doi.org/10.1038/s41392-023-01556-8
Zemerova T.P. (2022). PIEZO1 gene: [Electronic resource] // GENO MAP Genetic encyclopedia. – URL: https://www.genokarta.ru/gene/PIEZO1
Mathupala SP, Pedersen PL. (2010). Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target. Cancer Biol Ther.,15;9(12):1053-6. doi: 10.4161/cbt.9.12.12451. Epub 2010 Jun 21. PMID: 20581475; PMCID: PMC3385865
Liao Y, Hao Y, Chen H, He Q, Yuan Z , Cheng J. (2015). Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death. Protein Cell.,6(6):434-42. doi:10.1007/s13238-015-0144-6 . Epub 2015 Mar 11. PMID: 25753332; PMCID: PMC4444813
Baines CP. (2010). The cardiac mitochondrion: nexus of stress. Annu Rev Physiol.,72:61-80. doi: 10.1146/annurev-physiol-021909-135929 . PMID: 20148667
Baines CP. The mitochondrial permeability transition pore and the cardiac necrotic program. Pediatric Cardiol. 2011 Mar;32(3):258-62. doi:10.1007/s00246-010-9880-9. Epub 2011 Jan 6. PMID: 21210090
Szabó I, Zoratti M. (1993). The mitochondrial permeability transition pore may comprise VDAC molecules. I. Binary structure and voltage dependence of the pore. FEBS Lett.,13;330(2):201-5. doi: 10.1016/0014-5793(93)80273-w. PMID: 7689983
Crompton M, Virji S, Ward JM. (1998)Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. Eur J Biochem.,258(2):729-35. doi: 10.1046/j.1432-1327 .1998.2580729.x. PMID: 9874241
Kowaltowski AJ, Castilho RF, Vercesi AE. (1995). Ca(2+)-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state. Am J Physiol., 269(1 Pt 1):C141-7. doi: 10.1152/ajpcell.1995.269.1.C141. PMID: 7631741
Petrosillo G, Ruggiero FM, Pistolese M, Paradies G. (2004). Ca2+-induced reactive oxygen species production promotes cytochrome c release from rat liver mitochondria via mitochondrial permeability transition (MPT)-dependent and MPT-independent mechanisms: role of cardiolipin. J Biol Chem. 17;279(51):53103-8. doi: 10.1074/jbc.M407500200 . Epub 2004 Oct 8. PMID: 15475362
McCommis KS, Baines CP. (2012)The role of VDAC in cell death: friend or foe? Biochim Biophys Acta.1818(6):1444-50. doi: 10.1016/j.bbamem.2011.10.025 . Epub 2011 Oct 28. PMID: 22062421; PMCID: PMC3288473
Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD. (2007). Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol. May;9(5):550-5. doi: 10.1038/ncb1575 . PMID: 17417626; PMCID: PMC2680246
Vasilieva, I., Vasilieva, M., & Vasiliev, I. (2023). Recruitment Microcirculatory - Mitochondrial through a permissive systemic perfusion pressure combats microcirculatory - mitochondrial distress syndrome. Cases report. Special Journal of the Medical Academy and Other Life Sciences., 1(4). https://doi.org/10.58676/sjmas.v1i4.24
Vasiliev I., Vasilieva M., Vasilieva I. (2016). The medico legal indications and contraindications to the use ECMO and ECCO2R at Ali/Ards. United States: Project Proposed for Discussion and Study Wams.;6-9
Kociol R.D., Cooper L.T., Fang J.C., et al. (2020). Recognition and initial management of fulminant myocarditis: a scientific statement from the American Heart Association. Circulation. 2020; 141: e69-e92
https://doi.org/10.1161/CIR.0000000000000745
Vargas, A., Boivin, R., Cano, P. et al. (2017). Neutrophil extracellular traps are downregulated by glucocorticosteroids in lungs in an equine model of asthma. Respir Res; 18:207 https://doi.org/10.1186/s12931-017-0689-4
Chappell D., Hofmann-Kiefe, K., Jacob M. et al. (2009). TNF-α induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin. Basic Res Cardiol 104, 78–89. https://doi.org/10.1007/s00395-008-0749-5
Java A. J. Apicelli M. K. Liszewski et al. (2020). The complement system in COVID-19: friend and foe? JCI Insight, vol. 5, no. 15, Article ID e140711.
https://insight.jci.org/articles/view/140711
S. Kayser, R. Kunze, and A. Sheriff. (2021). Selective C-reactive protein apheresis for COVID-19 patients suffering from organ damage. Therapeutic Apheresis and Dialysis, vol. 25, no. 2, pp. 251-252. https://doi.org/10.1111/1744-9987.13532
Sheriff A, Kayser S, Brunner P and Vogt B (2021) C-Reactive Protein Triggers Cell Death in Ischemic Cells. Front. Immunol. 12:630430. doi: 10.3389/fimmu.2021.630430
Zahra Alipour, Somayeh Zarezadeh, Ali Akbar Ghotbi-Ravandi. (2023).doi: 10.1055/a-2209-6357
Xie Y, Choi T, Al-Aly Z. (2023). Association of Treatment with Nirmatrelvir and the Risk of Post–COVID–19 Condition. JAMA Intern Med.,183(6):554–564.
doi:10.1001/jamainternmed.2023.0743
Anastassopoulou C, Hatziantoniou S, Boufidou F, Patrinos GP, et al. (2022). Tsakris A. The Role of Oral Antivirals for COVID-19 Treatment in Shaping the Pandemic Landscape. Journal of Personalized Medicine.,12(3):439. https://doi.org/10.3390/jpm12030439
Ben-Mordechai T, Palevski D, Glucksam-Galnoy Y, Elron-Gross I. et al. ( 2015). Targeting Macrophage Subsets for Infarct Repair. Journal of Cardiovascular Pharmacology and Therapeutics; 20(1):36-51. doi:10.1177/1074248414534916
Jae W. Lee, Xiaohui Fang, Anna Krasnodembskaya, James P. Howard et al. (2011). Concise Review: Mesenchymal Stem Cells for Acute Lung Injury: Role of Paracrine Soluble Factors, Stem Cells, Volume 29, Issue 6, Pages 913–919, https://doi.org/10.1002/stem.643
Buijsers B., Yanginlar C., Maciej-Hulme M. L., et al, (2020). Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients, eBioMedicine ; 59, Article ID 102969, 2020. doi:https://doi.org/10.1016/j.ebiom.2020.102969
Ronco C, Ricci Z, Husain-Syed F. From Multiple Organ Support Therapy to Extracorporeal Organ Support in Critically Ill Patients. Blood Purif. 2019;48(2):99-105. doi: 10.1159/000490694. Epub 2019 Apr 26. PMID: 31030203
Vasiliev I., Calalb I., Cacian M., Thîbîrnac I., et al. (2007). Successful Treatment of Disseminated Intravascular Coagulation Syndrome in Obstetrics. Reports and Abstracts. 2nd White Sea Symposium of the All-Russian Conference with International Participation Actual problems of Anesthesiology and Intensive Therapy. Arkhangelsk. The chairman of the Conference, Professor E. Nedashkovsky, founder of the anesthesiology and resuscitation school of the European North of Russia., 106-108. https://anesth.ru/CONTENT/BEL%20SYMPOSIUM/BS-ABSTRACTS.pdf
Cutolo M, Paolino S, Smith V. (2020). Evidences for a protective role of vitamin D in COVID-19RMD Open 2020;6: e001454. doi: 10.1136/rmdopen-2020-001454
Cojocaru Victor, Ceban Emil, Vasilieva Irina, Vasilieva Maria, Vasiliev I. et al. (2020). Tödliche β-SARS - Cov-2 COVID 19 ist noch kein Satz. Published on LinkedIn. WAMS.
Cojocaru V., Ceban E., Groppa S., Vasilieva Maria, Vasilieva Irina, et al. (2020). Como testigo, salvando su propia vida del SARS-COV-2 / COVID19. Published on LinkedIn. WAMS
Vasilieva Irina, Vasilieva Maria, & Vasiliev, I. (2023). A Intralipid blocks the entry of the SARS. Special Journal of the Medical Academy and Other Life Sciences., 1(3). https://doi.org/10.58676/sjmas.v1i3.15
Vasiliev I., Creciun A. (1986). Cases of anaphylactic shock and tactics emergency therapy. Corr Med.; 5:51-53
Vasiliev I. Ceban N. (1989). The lymphotropic therapy with lymph stimulation in complex treatment of exotoxin shock. Health Care.; 2: 52-53.
Raghavendra Rao. M.V., M M Karindas, Ilie Vasiliev, Mohammed Ismail Nizami et al. (2022). Chronic Obstructive Pulmonary Disease (COPD)--Failing to Prepare Means Preparing to Fail. International Journal of Medical Science and Current Research; 5:5:673-681.
Mirta D Ambra M*,Ilie Vasiliev, Valeri Shevchenko. (2019). When the Trauma is Serious. American Journal of Biomedical Science and Research., 2(6). AJBSR.MS.ID.000616. DOI:10.34297/AJBSR.2019.02.000616
Mirta D’ Ambra. (2019). CDC Alert for Hospital Infections due to Candida Auris Multiresistant. American Journal of Biomedical Science & Research., 2:3
Ignatenco Sergiu, Vasilieva Irina, Crăciun, Ion. (2020). Temporary closure of the abdominal cavity in patients operated with mesenteric ischemia. In: Congress dedicated to the 75th anniversary of the founding of the "Nicolae Testemițanu" State University of Medicine and Pharmacy, October 21-23, 2020, Chişinău. Chisinau:” Nicolae Testemițanu" State University of Medicine and Pharmacy, R: 417. https://ibn.idsi.md/ro/vizualizare_articol/126122
Vasiliev Ilie. (2020). Modern intensive care is defeating the fatal SARS-Cov 2/COVID-19. Special Issue • S5 EuroSciCon Conference on Biotechnology & Bioengineering | Netherlands
Cojocaru V., Ceban E., Vasilieva Irina, Vasilieva Maria, Groppa S. et al. (2020). Mortel SARS - Cov-2 / COVID19 peut être vaincu. Published on LinkedIn. WAMS
Vasiliev I., Vasilieva Maria., Vasilieva Irina., Litarczek G., Friptu V., Gladun S. (2018). Suspending Microcirculatory-Mitochondrial Distress Syndrome by Recruiting Microcirculatory-Mitochondrial Disorders of Obstetric Critical Situations. Scientific Coordinator. Professor Dr. Onofriescu. E-poster. Iasi, Romania: National Congressional Society of Obstetric and Gynecological Society of Romania. Sum of Summaries.; 41.
M.V. Raghavendra Rao, Vijaykumar Chennamchetty, M M Karindas, Ilie Vasiliev, et al. (2022).” Breathing Lung Transplantation” - A Road to Relief New Lungs with Old Vessels. International Education & Research Journal; 8:7: 36-39.
https://ierj.in/journal/index.php/ierj/article/view/2533/2560
Vasilieva M., Groppa S. (2023). Nanotechnology - progress in neuromodulation. Collection of Abstracts. Research in Biomedicine and Health. Fundamental Problems of Medicine: Quality. Excelente and Performance. Annual Scientific Conference. October. 18-20. Current issues in neuroscience. Moldovan Journal of Health Sciences; 3:10: Annex 1: 394. https://ibn.idsi.md/ro/vizualizare_articol/194517
Bejenari A., Vasilieva M., Gasnaș A., Bondarciuc A., et al. (2023). Bacterial Meningoencephalitis during pregnancy. Case report. Collection of Abstracts. Research in Biomedicine and Health. Fundamental Problems of Medicine: Quality. Excelente and Performance. Annual Scientific Conference. October. 18-20. Current issues in neuroscience. Moldovan Journal of Health Sciences; 3:10: Annex 1: 430.
https://ibn.idsi.md/ro/vizualizare_articol/194599
Efremova D., Ciobanu N., Glavan D., Leahu P., Racila R., Bălănuță T., Matei A. , Vasileva Maria, Bondarciuc A., Bejenari I., Cojocaru A., Groppa S. (2023). EPO-202. Gender-specific relationship between homocysteine levels and carotid atherosclerosis in apparently healthy individuals. Cerebrovascular diseases 2. Abstracts of the 9th Congress of the European Academy of Neurology June 2023. Budapest, Hungary. European Journal of Neurology, 30 (S1): 450.
https://www.ean.org/fileadmin/user_upload/ean/congress-2023/EAN2023AbstractBook.pdf
Vasilieva Maria, Istratii Diana, Zota Eremia, Crivorucica Igor, Vasilieva Irina, Groppa Stanislav. (2022). Hypokalemia- stroke mimic. Case report. In: European Journal of Neurology., S1:29:884. ISSN 1351-5101 CZU: 616-08-039.35+616.8-005
https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.15467
Efremova Daniela, Ciobanu Natalia, Glavan Danu, Leahu Pavel, Vasilieva Maria, Groppa Stanislav et al. (2023). Serum Urate Levels and Ultrasound Characteristics of Carotid Atherosclerosis across Obesity Phenotypes. In: Biomedicines.,11:1-12. ISSN -. doi:10.3390/biomedicines11071897
https://www.mdpi.com/2227-9059/11/7/1897
Efremova D., Ciobanu N., Glavan D., Leahu P., Racila R., BălănuțăT., Matei A., Vasilieva Maria, Bondarciuc A., Bejenari I., Cojocaru A., Groppa S. (2023). 995. Relevance of Body Mass Index- Dependent gradients of seric Uric Acid levels for Stroke prediction in apparently Healthy Individuals. © European Stroke Organisation 2023. European Stroke Organisation Conference ESOC 2023 Abstract Book May 2023. European Stroke Journal., 8;2(S).
https://journals.sagepub.com/doi/epub/10.1177/23969873231169660
Vasilieva Maria*. Istratii Diana, Crivorucica Igor, Zota Eremei, Vasilieva Irina, Groppa Stanislav. Severe Hypopotassemia as a Stroke Mimic. The 9-Th Edition of MedEspera. 12th-14th of May 2022. Chișinău. Republic of Moldova. 2022;205.
Irina Vasilieva. Maria Vasilieva. The role of social networks in reducing stress. The "8th International Summit on Neurology and Brain Disorders». Conference. June 17-18, 2022. Abu Dhabi, UAE. https://mobile.twitter.com/neurolexmeet
https://mobile.twitter.com/neurolexmeet/status/1537779323134164992/photo/1
Câlcai C., Hadjiu S., Revenco Ninel, Iavorschi E., Rodoman I., Vasilieva Maria. (2017). Evolutionary peculiarities of cerebral stroke in young children following craniocerebral trauma: clinical case. In: Bulletin of the Academy of Sciences of Moldova. Medical Sciences., 2(54):320-323. ISSN 1857-0011 https://ibn.idsi.md/ro/vizualizare_articol/54173
Chiosa V., Ciolac D., Chelban V., Gasnas D., Vataman A., Munteanu C., Groppa S., Leahu P., Condratiuc E., Aftene D., Dragan D., Racila R., Doten N., Stoianov N., Condrea A., Ropot D., Vasilieva Maria. (2021). Drug-resistant epilepsy: modern concepts, integrative mechanisms, and therapeutic advances. Moldovan Medical Journal., 64(4):72-85
Vasilieva Maria, Oglindă-Catirău G., Groppa S. (2022). Catamenial status epilepticus. A rare condition or an underdiagnosed event. In: MedEspera: International Medical Congress for Students and Young Doctors, Ed. 9th edition, 12-14 mai 2022 Chişinău. Chisinau, Republic of Moldova.,9:158.
https://ibn.idsi.md/vizualizare_articol/162821
Cucusciuc C., Vasilieva Maria, Zota E., Crivorucica I., Manea D., Groppa S. (2022). Bithalamic ischemic stroke. Clinical case. In: Moldovan Journal of Health Sciences.,3: An.1:29:285. ISSN 2345-1467. https://ibn.idsi.md/vizualizare_articol/167847
Vasilieva Maria, Oglinda-Catirau Gabriela. (2022). Benign paroxysmal positional vertigo in pregnancy. Report houses. In: Moldovan Journal of Health Sciences., 3: An.1:29: 94. ISSN 2345-1467. CZU: 616.831-005-036]:618.2-071
Vasilieva Irina, Vasilieva Maria, Vasiliev I., et al. (2020). Maria & Irina Vasilieva Syndrome Contributes to the manifestation of Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis Syndrome (CFS / ME). National Congress of UroGynecology. Supliment Ginecologia ro., 30: 4: Supl 2; 28.
http://revistaginecologia.ro/system/revista/53/1-42.pdf
Vasilieva Maria, Dmitriev Iu., Bejenari A., Gorincoi N., Aftene D. (2021). The “dual diagnosis” of pharmacoresistant epilepsy and psychogenic non-epileptic seizures. Clinical case. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova., (R):238. ISBN 978-9975-82-223-7 https://ibn.idsi.md/ro/vizualizare_articol/142105
Lisu M., Vasilieva M., Crivorucica I., Ciobanu V. et al. (2023). Limbis encephalitis is a very rare complication of the Epstein-Barr virus. Collection of Abstracts. Research in Biomedicine and Health. Current issues in neuroscience.: Quality. Excelente and Performance. Annual Scientific Conference. October. 18-20. Moldovan Journal of Health Sciences; 3:10: Annex 1: 395.
https://ibn.idsi.md/ro/vizualizare_articol/194514
Vasilieva Maria, Bejenari Irina, Gasnaş Alexandru, Manea Diana, Groppa Stanislav. Transient global amnesia as a possible manifestation after COVID-19 infection. Clinical cases. Conference "Research in biomedicine and health: quality, excellence, and performance" Chisinau, Moldova, October 20-22, 2021
https://ibn.idsi.md/vizualizare_articol/142081
https://ibn.idsi.md/sites/default/files/imag_file/217_4.pdf
Vasilieva Maria , Dmitriev Iulia, Bejenari Aliona, Gorincioi Nadejda, Aftene Daniela. The “dual diagnosis” of pharmacoresistant epilepsy and psychogenic non-epileptic seizures. Clinical case. Conference "Research in biomedicine and health: quality, excellence, and performance" Chisinau, Moldova, October 20-22, 2021
https://ibn.idsi.md/ro/vizualizare_articol/142105
https://ibn.idsi.md/sites/default/files/imag_file/238_2.pdf
Mirta D’Ambra, Vasiliev I., Karindas Mark. (2019). Small brain vessel disease. Biomedical Journal of Scientific & Technical Research., 19:14555-6 DOI: 10.26717/BJSTR.2019.19.003355
Diug V., Vasiliev I. (2018). Definitive Haemostasis in Hematoma Postpartum Massive Hemorrhage.The sum of Summaries. Iasi: National Conference.; 44-46
Raghavendra Rao, MM Karindas, Ilie Vasiliev, Chennamchetty Vijay Kumar et al. (2022) 'Is Covid Vaccine Immunity Success Story Gives “A Lot of Happy Tears”?', International Journal of Current Medical and Pharmaceutical Research, 08(07):294-300 doi: http://dx.doi.org/10.24327/23956429.ijcmpr20220069
Raghavendra Rao M.V. *, Srilatha Bashetti, A. Rekha, Swarna Deepak et al. (2023). Candor in medical laboratory management: “Quality is doing the right thing and making things right”. World Journal of Biology Pharmacy and Health Sciences., 13(03), 210–220.
doi: https://doi.org/10.30574/wjbphs.2023.13.3.0139
Vasilieva Irina, Vișnevchi A., Vasilieva Maria, & Vasiliev I. (2023). Total Quality Management as Predictor of Artificial Intelligence Ensures Competitive Marketing. Special Journal of the Medical Academy and Other Life Sciences., 1(8). https://doi.org/10.58676/sjmas.v1i8.47
Devaux CA, Camoin-Jau L. (2023). Molecular Mimicry of the Viral Spike in the SARS-CoV-2 Vaccine Possibly Triggers Transient Dysregulation of ACE2, Leading to Vascular and Coagulation Dysfunction Similar to SARS-CoV-2 Infection. Viruses. , 15(5):1045. https://doi.org/10.3390/v15051045
Wigner-Jeziorska P., Janik-Karpińska E., Niwald M, Saluk J., Miller E. (2023). Effect of SARS-CoV-2 Infection and BNT162b2 Vaccination on the mRNA Expression of Genes Associated with Angiogenesis. International Journal of Molecular Sciences., 24(22):16094. https://doi.org/10.3390/ijms242216094
Vasilieva Maria, Vasilieva Irina, Vasiliev I., Groppa S. et al. (2018). Neurovegetative Correction of Diencephalic – Hyperkinetic, Catabolic Adrenergic Syndrome. Journal of Clinical Research in Anesthesiology.;1(2):1-3.
https://asclepiusopen.com/journal-of-clinical-research-in-anesthesiology/volume-1-issue-2/5.pdf
Vasilieva Maria. (2018). An altered state of consciousness is a possible factor to amplify the therapeutic effect in the case of neurostimulation in chronic pain. In: MedEspera: International Medical Congress for Students and Young Doctors, Ed. 7th edition, May 3-5, 2018, Chisinau. Chisinau, Republic of Moldova: 7:56-57 https://ibn.idsi.md/ro/vizualizare_articol/112928
Chacin-Bonilla, L. and Bonilla, E. 2023. Melatonin and Covid-19: An opened Pandora's box and the hope for the time being. Melatonin Research. 6, 4 (Dec. 2023), 474-484. DOI: https://doi.org/https://doi.org/10.32794/mr112500163
C.M. Smith, J.R. Komisar, A. Mourad, B.R. Kincaid. (2020) COVID-19-associated brief psychotic disorder BMJ Case Rep. CP, 13, Article e236940 doi: 10.1136/bcr-2020-236940. PMID: 32784244; PMCID: PMC7418683.
C.J. Watson, R.H. Thomas, T. Solomon, B.D. Michael, T.R. Nicholson, T.A. (2021). Pollak COVID-19 and psychosis risk: real or delusional concern? Neurosci. Lett., 741 , Article 135491 doi: 10.1016/j.neulet.2020.135491. Epub 2020 Nov 18. PMID: 33220366.
L.F. Garcia. (2020). Immune response, inflammation, and the clinical spectrum of COVID-19. Front. Immunol., 11:1441. doi: 10.3389/fimmu.2020.01441. PMID: 32612615; PMCID: PMC7308593 .
N.F. Santos, A.P. Alho, I.D. Costa, L.P. Ferreira, E.H. Sêco. (2021). First-episode psychosis with delusional jealousy during SARS-CoV-2 infection: COVID-19 secondary psychosis or a trigger for a primary psychotic disorder? Prim. Care Companion CNS Disord., 23(5):21cr03070. doi: 10.4088/PCC.21cr03070. PMID: 34592800.
Y. Shi, Y. Wang, C. Shao, J. Huang, J. Gan, X. Huang, E. Bucci, M. Piacentini, G. Ippolito, G. Melino. (2020). COVID-19 infection: the perspectives on immune responses. Cell Death Differ.,27(5):1451-1454. doi: 10.1038/s41418-020-0530-3. Epub 2020 Mar 23. PMID: 32205856; PMCID: PMC7091918.
M.Z. Tay, C.M. Poh, L. Rénia, P.A. MacAry, L.F.P. Ng. (2020). The trinity of COVID-19: immunity, inflammation and intervention. Nat. Rev. Immunol., 20: 363–374. doi: 10.1038/s41577-020-0311-8. Epub 2020 Apr 28. PMID: 32346093; PMCID: PMC7187672.
S.P. Thomas. (2021). Psychosis Related to COVID-19: Reports of a Disturbing New Complication. Taylor & Francis.
https://doi.org/10.1080/01612840.2021.1873054
Lucette A. Cysique., David, Jakabek., Sophia G. Bracken. (2023). The kynurenine pathway relates to post-acute COVID-19objective cognitive impairment and PASC. Annals of Clinical and Translational Neurology., 10(8): 1338–1352 https://doi.org/10.1002/acn3.51825 https://onlinelibrary.wiley.com/doi/epdf/10.1002/acn3.51825
Guo, W., Porter, L.M., Crozier, T.W., Coates, et al. (2022). Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures. Life Sci., 5, e20210111 https://www.life-science-alliance.org/content/5/4/e202101116 140. Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N, Herrler T., et al. (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell.,181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5. PMID: 32142651; PMCID: PMC7102627
Ou T, Mou H, Zhang L, Ojha A, Choe H, Farzan M (2021) Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2. PLoS Pathog 17(1): e1009212.
https://doi.org/10.1371/journal.ppat.1009212
Cani M, Epistolio S, Dazio G, Modesti M, Salfi G, Pedrani M, Isella L, Gillessen S, Vogl UM, Tortola L, et al. Antiandrogens as Therapies for COVID-19: A Systematic Review. Cancers. 2024; 16(2):298.
https://doi.org/10.3390/cancers16020298
ELANE rs17223045C/T and rs3761007G/A variants: Protective factors against COVID-19. Biomol Biomed [Internet]. 2024 Jan. 15 [cited 2024 Apr. 28];:665–672. https://www.bjbms.org/ojs/index.php/bjbms/article/view/9940
Tovey MG, Lallemand C. (2011). Immunogenicity and other problems associated with the use of biopharmaceuticals. Ther Adv Drug Saf., 2(3):113-28. doi: 10.1177/2042098611406318. PMID: 25083207; PMCID: PMC4110816
Mohamed A Alfaleh, Reem M Alsulaiman, Sarah A Almahboub, Leena Nezamuldeen, et al. (2024). ACE2-Fc and DPP4-Fc decoy receptors against SARS-CoV-2 and MERS-CoV variants: a quick therapeutic option for current and future coronaviruses outbreaks, Antibody Therapeutics., 7, :1:53–66 https://doi. org/10.1093/abt/tbad030
Nathan G.F. Leborgne, Christelle Devisme Nedim Kozarac, Inês Berenguer Veiga, ет ал. (2024). Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation., JCI Insight., 9(7):e174133. https://doi.org/10.1172/jci.insight.174133
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Luay Alkazmi, Maisra M. El-Bouseary, et al. (2023). The Potential Nexus between Helminths and SARS-CoV-2 Infection: A Literature Review, Journal of Immunology Research., ID 5544819:14. https://doi.org/10.1155/2023/5544819
Abdullayev R, Gul F, Bilgili B, Seven S, Cinel I. (2022). Cytokine Adsorption in Critically Ill COVID-19 Patients, a Case-Control Study. Journal of Intensive Care Medicine; 37:9:1223-1228. doi:10.1177/08850666221085185
Morris C, Gray L, Giovannelli M. (2015). Early report: The use of CytosorbTM haemabsorption column as an adjunct in managing severe sepsis: initial experiences, review and recommendations. Journal of the Intensive Care Society; 16:3:257-264. doi:10.1177/1751143715574855
Xu Kaijin, Cai Hongliu, Shen, Yihong, Ni, Qin et al. (2020). Translation: Management of Coronavirus Disease 2019 (COVID-19): Experience in Zhejiang Province, China. Infectious Microbes & Diseases 2:2:55-63. doi: 10.1097/IM9.0000000000000023
Chen Y, Liang W, Yang S, et al. (2013). Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterization of the viral genome. Lancet., 381(9881):1916–1925 doi: 10.1016/S0140-6736(13)60903-4 . Epub 2013 Apr 25. PMID: 23623390; PMCID: PMC7134567.
Howlin R P et al. (2017). Low-dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis. Molecular Therapy 25 2104–16
doi: https://doi.org/10.1016/j.ymthe.2017.06.021
Cure, E., Kucuk, A. & Cumhur Cure, M. (2020). Cyclosporine therapy in cytokine storm due to coronavirus disease 2019 (COVID-19). Rheumatol Int 40, 1177–1179. https://doi.org/10.1007/s00296-020-04603-7
Bobulescu IA, Di Sole F, Moe OW. Na+/H+ exchangers: physiology and link to hypertension and organ ischemia. Curr Opin Nephrol Hypertens. 2005 Sep;14(5):485-94. doi: 10.1097/01.mnh.0000174146.52915.5d PMID: 16046909; PMCID: PMC2861558.
Moisieieva NV, Vlasova OV, Miahkokhlib AA. (2024). Aspects of pharmacotherapy with steroids in SARS-CoV-2 infection (literature review). Experimental and Clinical Medicine.,93(1):9. Inpress.
https://doi.org/10.35339/ekm.2024.93.1.mvm
Santo Banerjee, A. Gowrisankar. (2023). Fractal Signatures in the Dynamics of an Epidemiology. An Analysis of COVID-19 Transmission. Gowrisankar, D. Easwaramoorthy, ∗ R. Valarmathi, P.S. Eliahim Jeevaraj,Christo Ananth and Ilie Vasiliev. Chapter 7An Integrated Perspective of Fractal Time SeriesAnalysis for Infected Cases of COVID-19A. https://www.routledge.com/Fractal-Signatures-in-the-Dynamics-of-an-Epidemiology-An-Analysis-of-COVID-19/Banerjee-Gowrisankar/p/book/9781032327693
Gowrisankar A., Easwaramoorthy D., Valarmathi R., Eliahim Jeevaraj PS., Christo Ananth, Ilie Vasiliev. (2023). An Integrated Perspective of Fractal Time Series Analysis for Infected Cases of COVID-19. In Book: Santo Banerjee, A. Gowrisankar. (2023). Fractal Signatures in the Dynamics of an Epidemiology. An Analysis of COVID-19 Transmission. In Book: Santo Banerjee, A. Gowrisankar. (2023). Fractal Signatures in the Dynamics of an Epidemiology. An Analysis of COVID-19 Transmission.
Raghavendra Rao M.V., Vijay Kumar Chennamchetty, MM Karindas, Vasiliev Ilie et al. (2022). A Citation, Distinction, Honor, and Tribute To Frontline Corona Warriors'. International Journal of Current Medical and Pharmaceutical Research.,08(07):321-325
Vasilieva Maria. Bejenari Irina. Groppa Stanislav. (2021) Differential diagnosis of cacosmia and dysgeusia in the COVID-19 pandemic. Clinical case report. Journal of the Neurological Sciences. October. 2021; 429.119610:119781:71 doi: https://doi.org/10.1016/j.jns.2021.119781
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498521/
https://europepmc.org/article/pmc/pmc8498521
https://www.jns-journal.com/article/S0022-510X(21)02478-3/pdf
https://www.jns-journal.com/article/S0022-510X(21)02477-1/fulltext#relatedArticles
https://www.jns-journal.com/article/S0022-510X(21)02477-1/fulltext
Vasilieva Maria, Gasnaș Alexandru, Bejenati Irina, Vasilieva Irina, Manea Diana, Groppa Stanislav. (2021). Overlap mechanisms of transient global amnesia and COVID-19 infection: review. In: 7th Congress of the Society of Neurologists Issue of the Republic of Moldova, Ed. 7, September 16-18, 2021, Chisinau. Chisinau: Curier Medical Magazine., 64,R:50. ISSN 2537-6381 (Online) http://repository.usmf.md/handle/20.500.12710/18126
LRRC15 leucine-rich repeat-containing 15. (2023). https://www.ncbi.nlm.nih.gov/gene/13157834.
Vasilieva, I., Vasilieva, M., & Vasiliev, I. (2023). A Intralipid blocks the entry of the SARS. Special Journal of the Medical Academy and Other Life Sciences., 1(3).
https://hollis.harvard.edu/permalink/f/1mdq5o5/TN_cdi_crossref_primary_10_58676_sjmas_v1i3_15 doi: 10.58676/sjmas.v1i3.15
Vasilieva M., Condrea A., Gasnas A., Manea, D., Groppa S. (2021). Neurological complications of Herpes Zoster, during convalescence from COVID-19 infection: Two clinical cases European Journal of Neurology; 28(SUPPL1):822. Artigo em Inglês | EMBASE | ID: covidwho-1307832. WHO https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-1307832
Pleșca Iu., Vasilieva Maria, Turcan E., Cheianu E., Bălănuța T., Crivorucica I., Groppa Sergiu.( 2023). EPV-381. Miliary Tuberculosis with Central Nervous System Dissemination. Abstracts of the 9th Congress of the European Academy of Neurology June 2023. Budapest, Hungary. ePosters. European Journal of Neurology., 30 (S1):783. https://www.ean.org/fileadmin/user_upload/ean/congress-2023/EAN2023AbstractBook.pdf
Vasilieva Maria. (2020). Epileptic seizures – primary manifestation in cerebral autoimmune pathology. Differential diagnosis between MS and SLE (case study). In: Congress dedicated to the 75th anniversary of the founding of the "Nicolae Testemițanu" State University of Medicine and Pharmacy, October 21-23, 2020, Chişinău. Chisinau: USMF., R: 377.
https://ibn.idsi.md/ro/vizualizare_articol/126055
Ciolac D, Racila R, Duarte C, Vasilieva M, Manea D, Gorincioi N, Condrea A, Crivorucica I, Zota E, Efremova D, Crivorucica V, Ciocanu M, Movila A, Groppa SA. Clinical and Radiological Deterioration in a Case of Creutzfeldt-Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration. Biomedicines. 2021 Nov 19;9(11):1730. doi: 10.3390/biomedicines9111730 . PMID: 34829958; PMCID: PMC8615966. https://doi.org/10.3390/biomedicines9111730
https://pubmed.ncbi.nlm.nih.gov/34829958/
Racila., Ciolac D., Leahu P., Gasnaș A., Gorincioi N., Chiosa V., Munteanu C., Dragan D., Vasilieva Maria, GROPPA S. MD, PhD, Academician, Professor. (2021). Boosting Cortical Inhibition with Theta Burst TMS in a Case of Super-Refractory Status Epilepticus International Congress "American Clinical Neurophysiology Society 2021 Annual Meeting and Courses". Organizers - American Clinical Neurophysiology Society, February 10-14, 2021. E-poster., 3
https://www.acns.org/UserFiles/file/am21-eposter-abstracts.pdf
Cojocaru Victor, Ceban Emil, Vasilieva Irina, Vasilieva Maria., Vasiliev I., et al. (2020). Successful Resuscitation of Deadly SARS - Cov-2 / COVID-19. Bioinformatics & Proteomics Open Access Journal.;4:1. https://medwinpublishers.com/BPOJ/successful-resuscitation-of-deadly-sars-cov2-covid19.pdf
Raghavendra Rao, Hitesh Lakshmi Billa, A Rekha, Sireesha Bala, et al. (2023). Is H3N2 Influenza flare-up and troubling like COVID? World Journal of Biology Pharmacy and Health Sciences., 14(01): 020–030. DOI: https://doi.org/10.30574/wjbphs.2023.14.1.0148
M M Karindas, Ilie Vasiliev, Raghavendra Rao, M.V. (2022). Death of a doctor is the death of a community. Indian Journal of Medical and Allied Research., 11:1:1-2
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