Obesity and endometrial cancer: the role insulin resistance and adipokines

Authors

DOI:

https://doi.org/10.58676/sjmas.v1i2.12

Keywords:

Obesity, endometrial cancer, insulin resistance

Abstract

Obesity has shaped the global pandemic as a major health problem. It is related to chronic metabolic diseases and cancer development, like endometrial cancer. Recent studies have revealed a strong correlation between higher Body Mass Index (BMI) and endometrial cancer, predicting that a higher BMI is a leading cause of endometrial cancer by disrupting the balance of adipocytokines and hormones. This article reviews the current scientific knowledge on the relationship between obesity and endometrial cancer and the role of insulin resistance and adipokines. It also addresses the necessity for additional studies to thoroughly comprehend the underlying processes and create efficient methods for preventing and treating endometrial cancer in obese people.

References

Arnold, M., Pandeya, N., Byrnes, G., Renehan, A. G., Stevens, G. A., Ezzati, M., . . . Dikshit, R. J. T. l. o. (2015). Global burden of cancer attributable to high body-mass index in 2012: a population-based study. 16(1), 36-46.

Arroyo, C., & Mincey, K. (2016). Obesity Epidemiology Worldwide. Gastroenterology Clinics of North America, 45, 571-579. doi:10.1016/j.gtc.2016.07.012

Ashizawa, N., Yahata, T., Quan, J., Adachi, S., Yoshihara, K., & Tanaka, K. J. G. o. (2010). Serum leptin–adiponectin ratio and endometrial cancer risk in postmenopausal female subjects. 119(1), 65-69.

Bandini, M., Gandaglia, G., & Briganti, A. J. C. O. i. U. (2017). Obesity and prostate cancer. 27(5), 415-421.

Boroń, D., Nowakowski, R., Grabarek, B. O., Zmarzły, N., & Opławski, M. J. J. o. C. M. (2021). Expression pattern of leptin and its receptors in endometrioid endometrial cancer. 10(13), 2787.

Chen, D.-C., Chung, Y.-F., Yeh, Y.-T., Chaung, H.-C., Kuo, F.-C., Fu, O.-Y., . . . Yuan, S.-S. F. J. C. l. (2006). Serum adiponectin and leptin levels in Taiwanese breast cancer patients. 237(1), 109-114.

Cust, A. E., Kaaks, R., Friedenreich, C., Bonnet, F., Laville, M., Lukanova, A., . . . Metabolism. (2007). Plasma adiponectin levels and endometrial cancer risk in pre-and postmenopausal women. 92(1), 255-263.

Davis, R. J. J. J. o. B. C. (1993). The mitogen-activated protein kinase signal transduction pathway. 268(20), 14553-14556.

Deng, J., Grande, F., & Neamati, N. J. C. c. d. t. (2007). Small molecule inhibitors of Stat3 signaling pathway. 7(1), 91-107.

Funaki, M., Katagiri, H., Inukai, K., Kikuchi, M., & Asano, T. J. C. s. (2000). Structure and function of phosphatidylinositol-3, 4 kinase. 12(3), 135-142.

Gao, J., Tian, J., Lv, Y., Shi, F., Kong, F., Shi, H., & Zhao, L. J. C. s. (2009). Leptin induces functional activation of cyclooxygenase‐2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. 100(3), 389-395.

Gunter, M. J., Hoover, D. R., Yu, H., Wassertheil-Smoller, S., Manson, J. E., Li, J., . . . Prevention. (2008). A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer. 17(4), 921-929.

Kelesidis, I., Kelesidis, T., & Mantzoros, C. J. B. j. o. c. (2006). Adiponectin and cancer: a systematic review. 94(9), 1221-1225.

Müssig, K., Häring, H.-U. J. E., endocrinology, c., & diabetes. (2010). Insulin signal transduction in normal cells and its role in carcinogenesis. 118(06), 356-359.

Ogawa, K., Sun, C., & Horii, A. J. O. r. (2005). Exploration of genetic alterations in human endometrial cancer and melanoma: distinct tumorigenic pathways that share a frequent abnormal PI3K/AKT cascade. 14(6), 1481-1485.

Onstad, M. A., Schmandt, R. E., & Lu, K. H. J. J. o. C. O. (2016). Addressing the role of obesity in endometrial cancer risk, prevention, and treatment. 34(35), 4225.

Organization, W. H. (2000). Obesity: preventing and managing the global epidemic.

Rodriguez, A. M., Polychronopoulou, E., Hsu, E., Shah, R., Lamiman, K., & Kuo, Y.-F. J. G. o. (2021). Factors associated with endometrial cancer and hyperplasia among middle-aged and older Hispanics. 160(1), 16-23.

Saliha, S. (2021). Obesity and Endometrial Cancer. In R. Venketeshwer & R. Leticia (Eds.), Role of Obesity in Human Health and Disease (pp. Ch. 4). Rijeka: IntechOpen.

Tewari, S., Vargas, R., & Reizes, O. J. A. o. t. N. Y. A. o. S. (2022). The impact of obesity and adipokines on breast and gynecologic malignancies. 1518(1), 131-150.

Tzenios, N., Tazanios, M., & Chahine, M. (2022a). In the United States, Obesity Is So Prevalent. Could It Be Described as a Pandemic?

Tzenios, N., Tazanios, M., & Chahine, M. (2022b). The Relationship between Association between Blood Pressure and Risk of Cancer Development.

Tzenios, N. . (2019). The Impact of Health Literacy on Employee Productivity: An Empirical Investigation . Empirical Quests for Management Essences, 3(1), 21–33. Retrieved from https://researchberg.com/index.php/eqme/article/view/83

Tzenios, N. (2019). The Determinants of Access to Healthcare: A Review of Individual, Structural, and Systemic Factors. Journal of Humanities and Applied Science Research, 2(1), 1–14. Retrieved from https://journals.sagescience.org/index.php/JHASR/article/view/23

Tzenios, N. . (2020). Examining the Impact of EdTech Integration on Academic Performance Using Random Forest Regression. ResearchBerg Review of Science and Technology, 3(1), 94–106. Retrieved from https://researchberg.com/index.php/rrst/article/view/84

Tzenios, N. (2023). A New Hallmark of Cancer: Stemness. Special Journal of the Medical Academy and Other Life Sciences., 1(1). https://doi.org/10.58676/sjmas.v1i1.3

Sharma, P. R., & Tzenios, N. (2023). Impact of Cirrhosis and Alcohol on Mortality Rates and Mitigation Efforts. Special Journal of the Medical Academy and Other Life Sciences., 1(1). https://doi.org/10.58676/sjmas.v1i1.10

Professor Nikolaos Tzenios Ph.D., FRSPH, FRSM, FAAMFM, FWAMS, FMRS, AcIASS, mRSB, DABAAHP. (2022). CONTRIBUTE TO RAISING AWARENESS IN A COMMUNITY. EPRA International Journal of Multidisciplinary Research (IJMR), 8(12), 122–124. Retrieved from http://eprajournals.net/index.php/IJMR/article/view/1252.(https://doi.org/10.36713/epra12021)

Tzenios, N. (2020). Clustering Students for Personalized Health Education Based on Learning Styles. Sage Science Review of Educational Technology, 3(1), 22–36. Retrieved from https://journals.sagescience.org/index.php/ssret/article/view/22

Tzenios, N. (2022). Student-led Learning Theory. Cambridge Open Engage. https://doi.org/10.33774/coe-2022-0x2bx

Tzenios, N. (2022). Academic Doctoral Learning Plan. Cambridge Open Engage. https://doi.org/10.33774/coe-2022-7twh9

Tzenios N, Tazanios M, Chahine M. The Relationship between Association between Blood Pressure and Risk of Cancer Development. Preprints.org; 2022. https://doi.org/10.20944/preprints202211.0353.v1

Tzenios, N., Tazanios, M. E., & Chahine, M. (2022). Combining Influenza and COVID-19 Booster Vaccination Strategy to Improve Vaccination Uptake Necessary for Managing the Health Pandemic: A Systematic Review and Meta-Analysis. Vaccines, 11(1), 16. https://doi.org/10.3390/vaccines11010016

Tzenios, N. (2022). Interprofessional Program Design Project to improve Nursing students’ attitudes toward collaborative practice. Cambridge Open Engage. https://doi.org/10.33774/coe-2022-hsxz7

Tzenios, N.; Tazanios, M.; Chahine, M. The impact of BMI on Ovarian Cancer- An Updated Systematic Review and Metanalysis. Preprints 2022, 2022110251 (https://doi.org/10.20944/preprints202211.0251.v1)

van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J. (2009). Obesity and Cancer: The Role of Dysfunctional Adipose Tissue. Cancer Epidemiology, Biomarkers & Prevention, 18(10), 2569-2578. doi:10.1158/1055-9965.EPI-09-0372 %J Cancer Epidemiology, Biomarkers & Prevention

Yunusova, N. V., Kondakova, I. V., Kolomiets, L. A., Afanas' ev, S. G., Chernyshova, A. L., Kudryavtsev, I. V., & Tsydenova, A. A. J. A. P. J. o. C. O. (2018). Molecular targets for the therapy of cancer associated with metabolic syndrome (transcription and growth factors). 14(3), 134-140.

Zhang, Y., Liu, L., Li, C., & Ai, H. J. C. B. (2014). Correlation analysis between the expressions of leptin and its receptor (ObR) and clinicopathology in endometrial cancer. 14(5), 353-359.

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. J. N. (1994). Positional cloning of the mouse obese gene and its human homolog. 372(6505), 425-432.

Zhao, J., Xue, F.-X., Hua, S.-F., & Zhang, L.-Z. J. Z. f. c. k. z. z. (2007). Effects of insulin on proliferation and apoptosis of endometrial carcinoma cell. 42(10), 696-700.

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Published

2023-02-09

How to Cite

Tzenios, N., Chahine, M., & Tazanios, M. (2023). Obesity and endometrial cancer: the role insulin resistance and adipokines. Special Journal of the Medical Academy and Other Life Sciences., 1(2). https://doi.org/10.58676/sjmas.v1i2.12

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