Modern approaches to understanding pathogenetic link between arterial hypertension and renal failure from the point of view of evidence based medicine.

Abstract

Background: Renal failure and arterial hypertension are critical global health issues affecting millions worldwide. Hypertension, affecting over 1.13 billion individuals, is a significant risk factor for cardiovascular and renal diseases. Chronic kidney disease (CKD), affecting approximately 10% of the global population, significantly impacts morbidity, mortality, and socioeconomic wellbeing. The reciprocal relationship between hypertension and renal failure exacerbates these conditions, creating a detrimental cycle of worsening health.

Methods and Materials: This study employs a comprehensive review of epidemiological data, pathophysiological mechanisms, and evidence-based management strategies. The research focuses on the bidirectional link between arterial hypertension and renal failure, analyzing the shared pathophysiological pathways such as endothelial dysfunction, inflammation, oxidative stress, and the activation of the renin-angiotensin-aldosterone system (RAAS). Data from various clinical trials and epidemiological studies are synthesized to propose effective treatment and management plans.

Results: The findings indicate a strong reciprocal correlation between arterial hypertension and renal failure. Hypertension is prevalent in over 85% of CKD patients, and individuals with hypertension have a significantly higher risk of developing CKD. Shared pathophysiological mechanisms, such as endothelial dysfunction, inflammation, oxidative stress, and RAAS activation, contribute to the progression and worsening of both conditions. Effective management requires addressing these common mechanisms through evidence-based treatments like RAAS inhibitors and lifestyle modifications.

Conclusion: The study underscores the need for integrated management strategies targeting both arterial hypertension and renal failure. Early detection, prevention, and comprehensive treatment approaches are crucial for mitigating the health and socioeconomic impacts of these interrelated diseases. Future research should focus on novel therapeutic strategies and personalized medicine to improve patient outcomes and reduce the global healthcare burden.